Δημοσιεύσεις

Project Acronym: MAG-NANO-MEM
Title: Modeling and simulations of functionalized magnetic nanoparticles as drug delivery systems
Affiliation: biomedical research foundation, academy of athens
Pi: Zoe Cournia
Research Field: biochemistry, bioinformatics and life sciences

Magnetic nanoparticles coated with polyarabic acid demonstrate enhanced drug delivery and imaging properties for cancer theranostic applications
by Patitsa, Maria and Karathanou, Konstantina and Kanaki, Zoi and Tzioga, Lamprini and Pippa, Natassa and Demetzos, Constantinos and Verganelakis, Dimitris A. and Cournia, Zoe and Klinakis, Apostolos
Abstract:
Therapeutic targeting of tumor cells with drug nanocarriers relies upon successful interaction with membranes and efficient cell internalization. A further consideration is that engineered nanomaterials should not damage healthy tissues upon contact. A critical factor in this process is the external coating of drug delivery nanodevices. Using in silico, in vitro and in vivo studies, we show for the first time that magnetic nanoparticles coated with polyarabic acid have superior imaging, therapeutic, and biocompatibility properties. We demonstrate that polyarabic acid coating allows for efficient penetration of cell membranes and internalization into breast cancer cells. Polyarabic acid also allows reversible loading of the chemotherapeutic drug Doxorubicin, which upon release suppresses tumor growth in vivo in a mouse model of breast cancer. Furthermore, these nanomaterials provide in vivo contrasting properties, which directly compare with commercial gadolinium-based contrasting agents. Finally, we report excellent biocompatibility, as these nanomaterial cause minimal, if any cytotoxicity in vitro and in vivo. We thus propose that magnetic nanodevices coated with polyarabic acid offer a new avenue for theranostics efforts as efficient drug carriers, while providing excellent contrasting properties due to their ferrous magnetic core, which can help the future design of nanomaterials for cancer imaging and therapy.
Reference:
Magnetic nanoparticles coated with polyarabic acid demonstrate enhanced drug delivery and imaging properties for cancer theranostic applications (Patitsa, Maria and Karathanou, Konstantina and Kanaki, Zoi and Tzioga, Lamprini and Pippa, Natassa and Demetzos, Constantinos and Verganelakis, Dimitris A. and Cournia, Zoe and Klinakis, Apostolos), In Scientific Reports, volume 7, 2017.
Bibtex Entry:
@article{Patitsa2017,
 author = {Patitsa, Maria
		and Karathanou, Konstantina
			and Kanaki, Zoi
			and Tzioga, Lamprini
			and Pippa, Natassa
			and Demetzos, Constantinos
			and Verganelakis, Dimitris A.
			and Cournia, Zoe
			and Klinakis, Apostolos},
 title = {Magnetic nanoparticles coated with polyarabic acid demonstrate enhanced drug delivery and imaging properties for cancer theranostic applications},
 journal = {Scientific Reports},
 year = {2017},
 bibyear = {2017},
 volume = {7},
 number = {1},
 pages = {775},
 abstract = {Therapeutic targeting of tumor cells with drug nanocarriers relies upon successful interaction with membranes and efficient cell internalization. A further consideration is that engineered nanomaterials should not damage healthy tissues upon contact. A critical factor in this process is the external coating of drug delivery nanodevices. Using in silico, in vitro and in vivo studies, we show for the first time that magnetic nanoparticles coated with polyarabic acid have superior imaging, therapeutic, and biocompatibility properties. We demonstrate that polyarabic acid coating allows for efficient penetration of cell membranes and internalization into breast cancer cells. Polyarabic acid also allows reversible loading of the chemotherapeutic drug Doxorubicin, which upon release suppresses tumor growth in vivo in a mouse model of breast cancer. Furthermore, these nanomaterials provide in vivo contrasting properties, which directly compare with commercial gadolinium-based contrasting agents. Finally, we report excellent biocompatibility, as these nanomaterial cause minimal, if any cytotoxicity in vitro and in vivo. We thus propose that magnetic nanodevices coated with polyarabic acid offer a new avenue for theranostics efforts as efficient drug carriers, while providing excellent contrasting properties due to their ferrous magnetic core, which can help the future design of nanomaterials for cancer imaging and therapy.},
 issn = {2045-2322},
 doi = {10.1038/s41598-017-00836-y},
 url = {https://doi.org/10.1038/s41598-017-00836-y},
}