Δημοσιεύσεις

Project Acronym: AmyloidDiabetes
Title: Computational and Structural Studies of Amyloidogenic Proteins related to Type II Diabetes
Affiliation: national and kapodistrian university of athens
Pi: Vassiliki Iconomidou
Research Field: biochemistry, bioinformatics and life sciences

αCGRP, another amyloidogenic member of the CGRP family
by Paraskevi L. Tsiolaki, Georgia I. Nasi, Fotis A. Baltoumas, Nikolaos N. Louros, Vassiliki Magafa, Stavros J. Hamodrakas and Vassiliki A. Iconomidou
Abstract:
The Calcitonin-gene related peptide (CGRP) family is a group of peptide hormones, which consists of IAPP, calcitonin, adrenomedullin, intermedin, αCGRP and βCGRP. IAPP and calcitonin have been extensively associated with the formation of amyloid fibrils, causing Type 2 Diabetes and Medullary Thyroid Carcinoma, respectively. In contrast, the potential amyloidogenic properties of αCGRP still remain unexplored, although experimental trials have indicated its presence in deposits, associated with the aforementioned disorders. Therefore, in this work, we investigated the amyloidogenic profile of αCGRP, a 37-residue-long peptide hormone, utilizing both biophysical experimental techniques and Molecular Dynamics simulations. These efforts unravel a novel amyloidogenic member of the CGRP family and provide insights into the mechanism underlying the αCGRP polymerization.
Reference:
αCGRP, another amyloidogenic member of the CGRP family (Paraskevi L. Tsiolaki, Georgia I. Nasi, Fotis A. Baltoumas, Nikolaos N. Louros, Vassiliki Magafa, Stavros J. Hamodrakas and Vassiliki A. Iconomidou), In Journal of Structural Biology, volume 203, 2018.
Bibtex Entry:
@article{TSIOLAKI201827,
 title = {αCGRP, another amyloidogenic member of the CGRP family},
 journal = {Journal of Structural Biology},
 volume = {203},
 number = {1},
 pages = {27 - 36},
 year = {2018},
 bibyear = {2018},
 issn = {1047-8477},
 doi = {10.1016/j.jsb.2018.02.008},
 url = {http://www.sciencedirect.com/science/article/pii/S1047847718300625},
 author = {Paraskevi L. Tsiolaki and Georgia I. Nasi and Fotis A. Baltoumas and Nikolaos N. Louros and Vassiliki Magafa and Stavros J. Hamodrakas and Vassiliki A. Iconomidou},
 abstract = {The Calcitonin-gene related peptide (CGRP) family is a group of peptide hormones, which consists of IAPP, calcitonin, adrenomedullin, intermedin, αCGRP and βCGRP. IAPP and calcitonin have been extensively associated with the formation of amyloid fibrils, causing Type 2 Diabetes and Medullary Thyroid Carcinoma, respectively. In contrast, the potential amyloidogenic properties of αCGRP still remain unexplored, although experimental trials have indicated its presence in deposits, associated with the aforementioned disorders. Therefore, in this work, we investigated the amyloidogenic profile of αCGRP, a 37-residue-long peptide hormone, utilizing both biophysical experimental techniques and Molecular Dynamics simulations. These efforts unravel a novel amyloidogenic member of the CGRP family and provide insights into the mechanism underlying the αCGRP polymerization.},
}